Manufacturers, importers and suppliers of medicinal products, medical devices, foods and cosmetics must comply and closely monitor the requirements of the EU's REACH Regulation. REACH imposes rigorous requirements additional to EU product-specific vertical legislation. This article sets out the key aspects of the REACH regulatory framework, in particular the main REACH requirements, medicinal products, food and feedingstuffs, medical devices, cosmetic products, and packaging. It also considers legal entities, foreign manufacturers, Only Representatives and third party representatives, and SIEFS, data sharing and consortia.