A Practice Note providing a broad overview of the role of the various federal agencies that license, regulate, or oversee transportation logistics in the commercial supply chain. These include the Department of Transportation (DOT) and its agencies (such as the Federal Aviation Administration (FAA), Federal Highway Administration (FHWA), Federal Motor Carrier Safety Administration (FMCSA), Federal Railroad Administration (FRA), Federal Transit Administration (FTA), Maritime Administration (MARAD), National Highway Traffic Safety Administration (NHTSA), Office of Inspector General (OIG), and Pipeline and Hazardous Materials Safety Administration (PHMSA)), as well as the Transportation Security Administration (TSA), the Surface Transportation Board (STB), the Federal Maritime Commission (FMC), and National Transportation Safety Board (NTSB).